Oxidized cholesteryl esters and inflammation
نویسندگان
چکیده
منابع مشابه
Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts.
The oxidative modification of low-density lipoprotein (LDL) has been implicated as a pro-atherogenic process in the pathogenesis of atherosclerosis. Macrophages rapidly take up oxidized LDL via scavenger-receptor-mediated pathways and thereby develop into lipid-laden foam cells. The uptake mechanism has been studied extensively and several types of scavenger receptors have been identified. In c...
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In the present experiments we have measured the liberation of [‘4C]adenosine derivatives and lactate from ‘synaptosome beds’ (de Belleroche & Bradford, 1972), prelabelled with [8-14C]adenosine and superfused with glucose/bicarbonate medium with or without metabolic inhibitors and depolarizing agents. To interpret our findings we have also measured ATP, ADP and AMP of the superfused synaptosomes...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2017
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2016.06.020